deletions | additions       diff --git a/To_verify_the_findin.tex b/To_verify_the_findin.tex  index 271d3cb..6bd0b2b 100644  --- a/To_verify_the_findin.tex  +++ b/To_verify_the_findin.tex 
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To verify the finding, we plot the proportions of read nucleotide  type at each time point using the raw data (see Figure \ref{fig:S6-822}). The two panels on top are based on Replicate I, while the two on the bottom are based on Replicate II. The control groups are the left two panels; the treatment groups are the right two panels. The color tiles on the top of each panel indicates the total read count at each time point. The complete transition of the nucleotide type in the treated group and nearly no change in the control group indicates strong drug effect. The consistent behavior across replicates enables us to conclude that S6-822 is a substation substitution  site due to the treatment.