Rosamaria Cannavo edited Abstract.tex  about 9 years ago

Commit id: 6ffb8b1b5a393e789e56c1485e4bc8f4c8d13613

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The abstract of the paper should be succinct; it must not exceed 300 words. Authors should mention the techniques used without going into methodological detail and should summarize the most important results. While the abstract is conceptually divided into three sections (Background, Methodology/Principal Findings, and Conclusions/Significance), please do not apply these distinct headings to the abstract within the article file. Please do not include any citations and avoid specialist abbreviations.  - "Coupled oscillators are not only of great biological interest, but also very interesting from a dynamical systems point of view. In a systems biology context, the interconnection between two periodic processes such the circadian rhythm and the cell cycle represents an ideal system that can be analyzed at the single-cell level. A  large dataset analysis from time-lapse imaging  of single mouse fibroblast showed, in our previous study, that circadian and  cell data  - non-parametric reconstruction cycle are robustly synchronized. This synchronization state is observed over a wide range of conditions and reflects predominant influence  of the dynamics  - identify new interaction  - cell cycle on the circadian cycle. Moreover, parameters of the coupling functions has been identified with stochastic modeling of two interacting phase oscillators. In this follow up study we performed a  thorough analysis of the model and achieved a non-parametric reconstruction of the dynamics, identifying new interaction points. This allows us to make more specific predictions on precise cell cycle events that could influence the circadian clock, such the condensation of chromosomes starting from prophase, and subsequently testing those prediction using further markers of cell cycle events."