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Rosamaria Cannavo edited Introduction.tex
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\textbf{\textit{General introduction on the clock and cell cycle}}
The circadian clock and the cell cycle oscillators represent two cellular processes having a period in the range of one day.
At the single-cell level, the circadian rhythm is carried out by a network of transcriptional and translational feedback loops that drive rhythmic expression of genes with a period of about 24
hours. (ref) hours\cite{Buhr_2013}. This cell autonomous rhythm is self-sustained (ref) and is considered to temporally orchestrate many important cell physiological processes such as metabolism (ref,ref), redox balance (ref) and chromatin landscapes/conformation (ref), {find other ph. Processes}.
The cell cycle can also be considered as a periodic process lasting on the order of one day in dividing mammalian cells (ref). Consequently, is reasonable to expect that, when circadian and cell cycles run in parallel in the same cell, their coupling could lead to synchronization.