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Walton Jones Abstract edit
almost 9 years ago
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\section*{Abstract}
Mammalian T-type Ca\textsuperscript{2+}
channels, which channels are encoded by three
separate genes (Ca\textsubscript{v}3.1, 3.2,
3.3), mediate 3.3).
Progress in identifying the physiological functions of the T-type channels has been hindered by likely compensation between the products of these three genes and by a lack of specific pharmacological inhibitors.
One of the few links that has been solidly attributed to a T-type current is the induction of
the deep sleep oscillations that promote sleep stability.
Invertebrates have only one T-type Ca\textsuperscript{2+} channel gene and its physiological functions are less well-studied.
We cloned DmCa\textsubscript{v}3, the only fly Ca\textsubscript{v}3 channel gene, and found that it shows broad expression across the brains of \emph{Drosophila melanogaster} adults.
Voltage-clamp analysis revealed that the biophysical and pharmacological properties of DmCa\textsubscript{v}3 are more similar to Ca\textsubscript{v}3.2 and Ca\textsubscript{v}3.3 than Ca\textsubscript{v}3.1.