Walton Jones Abstract edit  almost 9 years ago

Commit id: c86d1b4324e90b6f858dd0a20c7024a5235405f2

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\section*{Abstract}  Mammalian T-type Ca\textsuperscript{2+} channels, which channels  are encoded by three separate  genes (Ca\textsubscript{v}3.1, 3.2, 3.3), mediate 3.3).  Progress in identifying the physiological functions of the T-type channels has been hindered by likely compensation between the products of these three genes and by a lack of specific pharmacological inhibitors.  One of the few links that has been solidly attributed to a T-type current is  the induction of the deep  sleep oscillations that promote sleep stability. Invertebrates have only one T-type Ca\textsuperscript{2+} channel gene and its physiological functions are less well-studied.  We cloned DmCa\textsubscript{v}3, the only fly Ca\textsubscript{v}3 channel gene, and found that it shows broad expression across the brains of \emph{Drosophila melanogaster} adults.  Voltage-clamp analysis revealed that the biophysical and pharmacological properties of DmCa\textsubscript{v}3 are more similar to Ca\textsubscript{v}3.2 and Ca\textsubscript{v}3.3 than Ca\textsubscript{v}3.1.