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\label{fig:1}
{\bf
Comparison of Comparing the biophysical properties of DmCa\textsubscript{v}3 and rat Ca\textsubscript{v}3.1.}\\
{\bf(a)} (Left) Representative current traces through DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1 expressed in \emph{Xenopus} oocytes.
In 10 mM Ba\textsuperscript{2+}, currents were elicited by depolarizing step pulses
in separated by 10 mV increments from \textminus70 mV to +40 mV from a holding potential of \textminus90 mV.
(Right) I-V relationships of DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1.
Peak currents for each oocyte were normalized to the maximum
current recorded.
Averaged percent current.
Percent amplitudes (mean $\pm$ s.e.m.) from oocytes expressing DmCa\textsubscript{v}3 ($\fullmoon$) or Ca\textsubscript{v}3.1 ($\square$)
are plotted against
the test potentials and fitted with
the Boltzmann equation.
{\bf(b)} (Left) Steady-state inactivation was measured during voltage steps to \textminus20 mV after 10 s
prepulse prepulses to potentials between \textminus100 mV and \textminus40 mV.
(Right) Voltage-dependent activation and steady-state inactivation curves of DmCa\textsubscript{v}3 ($\fullmoon$, $\newmoon$) and Ca\textsubscript{v}3.1 ($\square$, $\blacksquare$)
were plotted and fitted with
the Boltzmann equation.
{\bf(c)} The activation time constant ($\tau$\textsubscript{act}) and inactivation time constant ($\tau$\textsubscript{inact}) of DmCa\textsubscript{v}3 ($\fullmoon$) and Ca\textsubscript{v}3.1 ($\square$) were obtained by
curve fitting the current traces with double
exponentials simultaneously. exponentials.
{\bf(d)} Voltage-dependent deactivation of DmCa\textsubscript{v}3 in HEK-293 cells.
Tail currents were elicited by application of repeated step pulses to \textminus20 mV for 10 ms, followed by various re-polarizing potentials
ranging from \textminus120 mV to \textminus50 mV.
Deactivation time constants were obtained
from by fitting tail current traces with a single exponential and plotted against re-polarizing potentials (n=6).
{\bf(e)} I\textsubscript{Ca}/I\textsubscript{Ba} ratios of DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1.
(Left) Representative current traces through DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1 measured in 10 mM Ba\textsuperscript{2+} or 10 mM Ca\textsuperscript{2+} elicited by
\textminus10 10 mV step pulses from a holding potential of \textminus90 mV.
Ba\textsuperscript{2+} currents are
represented in
black, black; Ca\textsuperscript{2+} currents are in grey.
(Middle) I-V relationships of DmCa\textsubscript{v}3 ($\fullmoon$}, $\newmoon$) and Ca\textsubscript{v}3.1 ($\square$, $\blacksquare$) in 10 mM Ba\textsuperscript{2+} (open) or 10 mM Ca\textsuperscript{2+}
(filled) solution. (filled).
(Right) The
ratios (I\textsubscript{Ca}/I\textsubscript{Ba}) of peak current
amplitude through ratios (I\textsubscript{Ca}/I\textsubscript{Ba}) for DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1 (n=5, 4) and
their relative slope conductance (G\textsubscript{MaxCa}/G\textsubscript{MaxBa})
(n=6, 4) in 10 mM Ca\textsuperscript{2+} and 10 mM
Ba\textsuperscript{2+} through DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1 (n=6, 4). Ba\textsuperscript{2+}.
Student's t-test,
**p$<$0.01, ***p$<$0.001. **\emph{p}$<$0.01, ***\emph{p}$<$0.001.
{\bf(f)} Nickel inhibition sensitivity of DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1.
(Left) Representative current traces of DmCa\textsubscript{v}3 and Ca\textsubscript{v}3.1 at the indicated
concentration of Ni\textsuperscript{2+}. Ni\textsuperscript{2+} concentrations.
(Right) Dose-response curves indicating Ni\textsuperscript{2+}-dependent inhibition of DmCa\textsubscript{v}3 ($\fullmoon$) and Ca\textsubscript{v}3.1 ($\square$) obtained by fitting the averaged data with the Hill equation.
