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Kyunghwa Jeong edited Results_sleep.tex
almost 9 years ago
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In mammals, two T-type channel subtypes of a1G and a1I involve in generation of neural oscillation in NREM sleep.
It is well established that flies have sleep-like state and share conserved mechanisms with mammals although it is still not clear whether flies have distinct sleep stages.
Interestingly, \emph{DmCa\textsubscript{v}3\textsuperscript{Gal4}} flies show increased sleep
that in 12h:12h light-dark cycle (LD) and this phenotype is particularly prominent in subjective daytime under continuous dark (DD) conditions (Fig. \ref{fig:3}c and d).
Increased sleep, however, was restored in \emph{DmCa\textsubscript{v}3\textsuperscript{Rescue}} flies to a level similar to that of \emph{w\textsuperscript{1118}} control flies (Fig. \ref{fig:3}c and d).
By measuring waking locomotor activity, we were able to confirm that the increased sleep of \emph{DmCa\textsubscript{v}3\textsuperscript{Gal4}} flies is not an artifact of a generalized reduction in movement. In fact, \emph{DmCa\textsubscript{v}3\textsuperscript{Gal4}} show slightly higher levels of waking activity than their respective controls (Fig. \ref{fig:3}e).
Fly sleep consists of a number of sleep episodes.
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