deletions | additions       diff --git a/Introduction.tex b/Introduction.tex  index dc9b04a..a63c339 100644  --- a/Introduction.tex  +++ b/Introduction.tex 
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\section*{Introduction}  T-type Ca\textsuperscript{2+} channels are a subfamily of voltage-dependent Ca\textsubscript{v}3 Ca\textsuperscript{2+}  channels (VDCCs) that produce low-voltage-activated (LVA) Ca\textsuperscript{2+} currents implicated in NREM sleep in mammals\cite{Lee:2004ey}. Three different genes encode the pore-forming alpha subunits of mammalian T-type channels, Ca\textsubscript{v}3.1, 3.2, and 3.3. Of these, Ca\textsubscript{v}3.1 and 3.3 are highly expressed in the thalamus, where the oscillations required for NREM sleep are generated\cite{PerezReyes:1998gn}.  Mice lacking Ca\textsubscript{v}3.1 show reduced delta-wave activity and reduced sleep stability, suggesting that mammalian T-type currents have a sleep-promoting or stabilizing function\cite{Lee:2004ey}. 
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We also generated several DmCa\textsubscript{v}3 mutant alleles and identified a defect in their sleep/wake cycles. Contrary to results in mammals, the fly T-type Ca\textsuperscript{2+} channel destabilizes sleep.  We anticipate that our findings will help clarify species-dependent differences in the \emph{in vivo} functions of T-type Ca\textsuperscript{2+} channel.