Broadband Untuned Active Cancellation and Phase Correction of Direct
Feedthrough Interference Enables 100-fold Improved Magnetic Particle
Imaging Detection
Abstract
Magnetic particle imaging (MPI) is a tracer imaging modality that
detects superparamagnetic iron oxide nanoparticles (SPIOs), enabling
sensitive, radiation-free imaging of cells and disease pathologies. The
arbitrary waveform relaxometer (AWR) is an indispensable platform for
developing magnetic nanoparticle tracers and evaluating tracer
performance for magnetic particle imaging applications. One of the
biggest challenges in arbitrary waveform excitation is direct
feedthrough interference, which is usually six orders of magnitude
larger than the signal from magnetic nanoparticles. This work will
showcase hardware that suppresses this interference by an order of
magnitude, increasing the dynamic range of the instrument and enabling
mass-limited detection at full scale range.