Potentiating light-harvest tactics through A-D-A structure:
repolarization tumor associated macrophage through phototherapy
Abstract
Aiming to decrease the recurrence of tumors and achieve patients’
satisfactory, the elicitation of immunotherapy and integrated
synergistic employment anew bright new down in oncotherapy, yet an
emergently challenging task. Especially, tumor-associated macrophages
(TAMs) regulation though light-induced photodynamic and photothermal
therapy (PDT and PTT) was regarded as a powerful approach, which focused
on systemic immune instead of tumor itself. Herein, this study published
an acceptor-donor-acceptor (A-D-A) aggregation-induced emission
luminogens (AIEgens), named TPA-2CN, which was applied as
photosensitizer (PSs) and photothermal agent (PTA). Attributing to the
A-D-A structure and AIE property, TPA-2CN owned higher molar absorption
coefficient and perfect templates in regulating radiative and
nonradiative transitions, which maximally utilized excited energy. The
generation of type I reactive oxygen pro-moted its application in
hypoxia tumor sites and the combination of hyperpyrexia forcefully
induced macrophages to polarization to-wards immune responses M1
phenotype. Both in vitro and in vivo, the successful reversion and
reprogramming of immune microenvironment was impressively proved. This
finding optimally concentrated immune therapy, PDT and PTT as one, and
exhibited excellent synergistic therapeutic effects with good biosafety.