Figure 1
- SODWTxCCS mice die early, are rescued by CuATSM. Caption pending figure replacement.
COX is deficient, likely cause for early death
It has been proposed that the early death seen in SODG93AxCCS mice is a result of cytochrome c oxidase (COX) deficiency caused by redistribution of copper, via CCS, to SOD instead of COX (Williams et al., 2016). We assayed COX activity in CNS tissue from SODWTxCCS mice to investigate the link with the early development crisis.