In this paper, a comparison of the Rational Unified Process (RUP) and Extreme Programming (XP) is discussed from a practical perspective. The paper starts with a short introduction to both software development methodologies and is followed by a description of similar research comparing XP and RUP. The aforementioned comparisons are from a more theoretical perspective. Therefore, this paper continues with a contribution comparing both methodologies from a practical perspective by combining multiple research sources. The conclusion of the similar comparison research is that XP and RUP are very different. After adding comparisons from a practical perspective however, the conclusion is that XP and RUP are in fact very similar when it comes to end result and usage.