MCI due to AD is the transition from normal cognition to dementia [Albert et al., 2011]. Accordingly, CVR abnormalities would be subtle or borderline which may partly explain ambiguous findings, particularly in MCI patients with a low vascular burden. Furthermore, considering the complexity of the cerebral microvasculature network the standard analysis of CVR might not reflect network-related subtle alterations. The standard analysis relies on separate brain regions (or the whole brain) rather than on brain networks.