On the other hand, in recent years graph theoretical analysis of large-scale structural correlation networks has shown its potential to reveal subtle cerebral pathological processes in MCI (Tijms et al., 2013, for a review). In principle, the same approach can be applied to cerebral blood flow (CBF) imaging for detecting possible subtle CVR abnormalities network related, especially local alterations. AD begins locally in the brain [Ingelsson et al., 2004; Villain et al., 2012].