The concept of clustering coefficient (C) was used to evaluate ACZ-induced local changes on the topology of CBFcorr networks. C is a measure of network segregation or local connectivity [Rubinov and Sporns, 2010; Bullmore and Bassett, 2011]. Therefore, it can be used to characterize ACZ-induced changes on local CBF co-variation (CBF ‘connectivity’). C is a higher order topological metric, in consequence, changes as a result of ACZ stimulation have no straightforward interpretation. However, its meaning becomes apparent when analyzed together with the changes of the correlation strength (CS) that is a low-level network metric with direct meaning. This approach provides clarity to the analysis [Bullmore and Bassett, 2011; Fornito et al., 2013].