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Bruce/Canoll research planning retreat agenda
 
Grand Vision
            -focus on low grade glioma (and subset of high grade glioma that act like LGG)
            -local delivery and immune modulation
            -local delivery of other chemotherapeutics
Bruce/Canoll research planning retreat agenda
 
Grand Vision
            -tumor bank/data base
                        Hire with Lassman
            -Immunology focused researcher
                        Hire Postdoc to replace JSS
            -local delivery and immune modulation
            -local delivery of other chemotherapeutics
            -Glioma/Brain tissue interactions (role in dz progression and potential therapeutic target)
           
Priority Issues
Staffing
Bruce/Canoll research planning retreat agenda
 
Grand Vision
            -focus on low grade glioma (and subset of high grade glioma that act like LGG)
            -local delivery and immune modulation
            -local delivery of other chemotherapeutics
            -Glioma/Brain tissue interactions (role in dz progression and potential therapeutic target)
           
Priority Issues
Staffing
            -lab manager
                        Jorge-(ordering, budgets, training, compliance, weekly lab meetings)
                        Hire (to either be manager or work for Jorge).
Bruce/Canoll research planning retreat agenda
 
Grand Vision
            -focus on low grade glioma (and subset of high grade glioma that act like LGG)
            -local delivery and immune modulation
            -local delivery of other chemotherapeutics
            -Glioma/Brain tissue interactions (role in dz progression and potential therapeutic target)
           
Priority Issues
Staffing
            -lab manager
                        Jorge-(ordering, budgets, training, compliance, weekly lab meetings)
                        Hire (to either be manager or work for Jorge).
            -tumor bank/data base
                        Hire with Lassman
            -Immunology focused researcher
                        Hire Postdoc to replace JSS
            -animal experiments focused researcher
            -GHP/tumor microenvironment focused researcher
 
Funding
            -CED R01
            -Myosin/Kinesin R01
            -OPC R01
            -Ribotag/Cannabis R03
            -ENDURES
            -Hubble
-CURE
            -others?
 
Collaborations
            -Peter Sims  (everything involving sequencing)
            -Jack Grinband (everything involving imaging)
-Elizabeth Hillman (In vivo Optical Imaging)
-Cathy Schevon and McKhann lab (Electrophysiolog studies)
-Jan Kitajewski (Notch)
-Tom Hei/Tony Want/ Simon Cheng (Radiation therapy)
 
Current Lab Projects
            -Pig CED (and corresponding mouse CED)
                        -Justin Randy Takeshi
            -CED of PD1 inhibitor
                        -Jenny,Liang Takeshi-Hire
            -OPC transformation/LGG model
                        -Angelina, Daniela,
            -Glioma induced Seizures
                        -Daniela, Brian,
            -Notch role in glioma progression and response to therapy
                        -Thanassis
 
Current and Priority Clinical Projects
            -Topotecan chronic CED
                        -IND, Justin Randy Adam
            -Subependymoma papers
                        -randy paper, Jenny paper, get sample from Orin
            -LGG vaccine trial –Write an IRB (review Parsa protocol) and get AGENUS to committ
                        -Randy, Justin, Jenny, New Hire, Peter Sims, Agenus
            -Vaccine for other types of brain tumors
                        -Randy, Chordoma and Meningioma
            -GHP 2.0 (BOLD, multiparametric mri, Fluorescein, single cell seq)
                        -Stephen Zach Jack Grinband
            -post-treatment recurrence vs pseudoprogression study (Radiopathologic correlation)
                        -Zach, Jack, Peter, Peter Chang, Lassman
            -Pineal Clinical Study (Resident, medical student, George Zanazzi)
 
Incorporate lab management issues into weekly meeting
Incorporate lab goals into weekly lab meeting-more regimented (12pm-1pm)
 
Weekly lab meeting agenda
Review of compliance (5 min)
Presentation of day (15-30 min)
Review of goals and status (10 min)
 
SPORE
Bruce (PI) Canoll (co-PI)
N of One (Califano)
Meeting with Lassman
Meeting with Emerson
Meetings with Califano Lasarella Iavarone Sims Rabadan, Roth, Seigelin, Iwamoto,  Zhiguo Zhang
Put together an internal advisory committee to vet projects
(Emmerson , Tycko, Dela Favara?, Dawn Hirshman, Al NewGut, Gary Schwartz, Mary Terry, Richard Baer, Regina Santella)
 
Potential Project
 
Immunotherapy-CED checkpoint inhibitors with/without vaccine
Bruce, New Recruit? Vs Agenes
 
Vaccine in LGG using TCR to monitor response
Sims Iwamoto
 
N of One  (treat prior to surgery)