Iraida Loinaz - Cidetec Spain - NanoPilot : A pilot plant under GMP for nanopharmaceuticals manufacturing
Funded by H2020, quality control and GMP grade nanomedicinial products for upscaling and clinical trial. 3 products already processed there : siRNA nanoformulate for topical treatment of ocular pain ; HIV nanovaccine ; Hyaluronan based particles for interstitial cystitis / painful bladder syndrome
Lucie Valero - UMRS1139/UMR8258 Paris Descartes ; Daniel Scherman et Nathalie Mignet - Design and evaluation of nanocarriers for the treatment of preeclampsia
PEGylated liposomes carries siRNA to reduce placental release of sFlt-1 \cite{Valero2017}.
Mark Grinstaff - Boston University - expansile nanoparticles for the treatment of intraperitoneal mesothelioma
Holds many patents and cofounder of
Hyperbranch technology, many projects in nanomaterials from his
group. Nanoparticles in acidic pH expand from 100nm to 1000nm, releasing drugs, burst organelles, stay stuck in tissues
\cite{Colby_2017}. Develop a concept of targeting tumor with empty nanoparticles first, inject free drugs to patients who will concentrate in nanoparticles within tumor tissue = Concept of loading and reloading nanomaterials within tissue
\cite{Colby2016}.
eNPs is effective to load paclitaxel and 4h post intraperitoneal injection, eNPs localize in tumors with persistent intratumoral retention for >14 days. Mesothelioma mice model survival is more than +50% when treated with loaded eNPs compared to PTX (standard of care doses) or eNPs alone.
# No targeting