One sentence 5-year old summary of intent:
It's hard to remove lots of genes and see their effect, even harder to pull out groups of genes. The field needs scalable ways to systematically dissect gene circuits and causal relations.
Classical genetic approaches to mapping genotypes to phenotypes leveraging population diversity can be confounded by layers of molecular machinery and length scales between the two. Experiments measuring the direct transcriptional effect of introduced mutations scale linearly with number of experiments in a way that prohibits large scale testing (largest experiments to our knowledge assay hundreds of perturbations followed by RNA-seq...Oren's CRISPR paper or project Achilles). eQTL mapping, while effective, is not suited for examining how gene inactivation effects percolate through genetic networks.