Background
CF3 is a common motif in radiopharmaceuticals that can be labelled with 18F or 11C. Methods to produce [18F]CF3-containing tracers give modest molar activity due to 18F/19F exchange. However, [11C]CHF3 can now be produced with high molar activity from cyclotron-produced [11C]CH4 and used for labelling a variety of molecules (1).