ET-743, aplidin and bryostatin-1 isolated from Mussels and tunicates cultivated in Mediterranean and Black Sea have been found to possess antitumor activity. Carotenoid fucoxantin from edible brown algae also act as sources of antitumor drugs derivatives. The consumption of brown macrophytes is linked to decrease in the risk of cancer development [9]. Polysaccharide extracted from Sargassum confusum inhibits sarcomas180 xenograft in mice, by promoting thymocytes and splenocytes [10]. Acidic sulphated polysaccharides obtained from the seaweed Ulva rigida used as an experimental immunostimulant, induced a more than two-fold increase in the expression of several chemokines (chemokine (C motif) ligand 1, chemokine (C-X-C motif) ligand 12, chemokine (C-C motif) ligand 22 and chemokine (C-X-C motif) ligand 14 (Cxcl14)) and the expression of IL6 signal transducer and IL12 receptor beta 1 [11]. Extracts of Caulerpa prolifera prevents (AFB(1))-initiated hepatotoxicity in female Sprague-Dawley rats by promoting significant increase in serum alpha fetoprotein, carcinoembryonic antigen, tumor necrosis factor alpha, nitric oxide, interleukin-1alpha, procollagen III and lipid peroxidation level in the liver and also a significant decrease in food intake, body weight, serum leptin, the activities of glutathione peroxidase, superoxide dismutase and DNA and RNA concentrations in the liver [12].