Title. Write a brief, informative title. Abbreviations should not be used in titles. It is important for literature retrieval to include in the title the key words that identify the nature of the subject matter, including, if applicable, the species on which the work is done.
Authors and affiliations. Authors are urged to include their full names, complete with first and middle names or initials. Academic degrees should not be included. The names and locations of institutions or companies should be given for all authors. Departments, units, or laboratories should also be specified. If several institutions are listed on a manuscript, it should be clearly indicated with which department and institution each author is affiliated by using corresponding superscript numbers.
Running title. A brief running title of no more than 60 characters should be provided. Choose the running title carefully, as it will be used in electronic alerting services and some mobile device applications. Abbreviations may be used in the running title.
Keywords. Provide 5 keywords identifying the subject of the manuscript.
Additional information. Include the following notes on the title page (if applicable) in this order:
- Financial support, including the source and number of grants, for each author
- Full name, mailing address, phone and fax numbers, and email address of the corresponding author
- A conflict of interest disclosure statement; additional information is available at this link: Conflict of Interest Policy
- Other notes about the manuscript as a whole, including the word count, and the total number of figures and tables Please note that, if you substantially exceed the word limit given for the type of article (see specific instructions for each journal), your manuscript may be returned.
For Clinical Cancer Research only, on a page between the title page and abstract you must provide a 150-word statement of translational relevance describing how the results might be applied to the future practice of cancer medicine.
The abstract must be concise, yet should accurately outline the content of the manuscript (see the Categories of Articles page of each journal for abstract length requirements for each type of article). Because these abstracts are used by secondary services (e.g., MEDLINE, Chemical Abstracts, Web of Science, Scopus), they should recapitulate in abbreviated form the purpose of the study and the experimental technique, results, and data interpretations. Data such as the number of test subjects and controls, strains of animals or viruses, drug dosages and routes of administration, tumor yields and latent periods, length of observation period, and magnitude of activity should be included. Vague, general statements such as "The significance of the results is discussed" or "Some physical properties were studied" should be avoided. Important terms relevant to the content of the manuscript should be incorporated into the abstract to assist indexers and searchers. Abbreviations should be kept to an absolute minimum; however, if they are needed, they must be explained at first mention within the abstract so that it can be understood as an independent unit from the remainder of the manuscript. Do not cite references in the abstract.
The introduction should provide a brief overview of the background and rationale for the study. It is not necessary to cite all of the background literature in the introduction. Brief reference to the most pertinent articles generally suffices to acquaint the reader with the findings of others in the field and with the problem or question that the investigation addresses.
Materials and Methods
Explanation of the experimental methods should be adequate for repetition by qualified investigators. Procedures that have been described in previous publications should not be described in detail but merely cited with appropriate references along with any modifications of the procedure. Only new and substantial modifications of previously published procedures need complete exposition. The sources of special chemicals or preparations used should be provided. Any commercial products that are mentioned should include the name of the manufacturer and catalog numbers.
Include a concise summary of the data presented in all display items (figures and tables). Excessive elaboration of data shown in display items should be avoided.
The data should be interpreted concisely without repeating material already presented in the Results section. Speculation is permissible, but it must be well founded, and discussion of the wider implications of the findings is encouraged.
Include the names of others contributing to the work who are not identified as authors.
Number the references in the order of their first mention in the text; cite only the number assigned to the reference. The reference list should be limited to only those citations essential to the presentation. Before submission of the manuscript, authors should verify the accuracy of all references and check that all references have been cited in the text. The AACR journals' reference style follows that of the Uniform Requirements for Manuscripts Submitted to Biomedical Journals. For manuscripts with more than 6 authors, the names of the first 6 authors must be listed, followed by "et al." For manuscripts with 6 or fewer authors, all authors should be listed.
Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, et al.
Differentiation therapy of acute promyelocytic 584 leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med1991;324:1385–93.
Yuspa SH, Hennings H, Roop D, Strickland J, Greenhalgh DA. Genes and mechanisms involved in malignant conversion. In: Harris CC, Liotta LA, editors. Genetic mechanisms in carcinogenesis and tumor progression. New York: Wiley-Liss; 1990. p.115–26.
Article in press
Articles in press may be listed among the references. The author must provide a DOI to the editor to verify that the article is in press at the indicated journal.