CARBON NANOTUBES MASSIVELY ENHANCE THE FIBRILLOGENESIS OF D76N (as can be observe in panel B of Figure 1)
It has been previously shown \cite{Linse_2007}, even though at pH 2.5, that nanoparticles enhance the rate of the protein fibrillation by decreasing the lag time of the nucleation. In the particular case of b2m, they found that NPs enhance the probability of appearance of a critical nucleus for nucleation of protein fibrils, with a strong relation between the shorter lag time (nucleation) and the nature of the particle surface.
Graphitic nanomaterials
From the review \cite{De_Leo_2015}
aminoacids and graphene
- AA-water interactions compete with AA-graphene interactions: water molecules have a negative influence on the binding of AA onto graphitic surface and there is a weakening for the final adsorption energy to graphene
- Arg (R) (positively charged) > Trp (W) (hydrophoic side chain) > Tyr (Y) (hydrophobic side chain) > His (H) (positively charged) > Gln (Q) (polar) are the residues more able to interact with the surface as the have bigger side chains that can maximize the vdW contact and with the aromatic parts are able to stack on the flat surface
- Arg (R), Gln (Q), Asn (N) and Lys (K) are the most interacting residues that spontaneously adsorb on graphitic surface