6. Acknowledgements:
This work was supported by the National Natural Science Foundation of China [No.82141119 and No.82070202], the Beijing Natural Science Foundation [No.7232058 and 7242053], the Capital’s Funds for Health Improvement and Research [No.2020-2-2093 and No.2022-2-1141], and Funding for Reform and Development of Beijing Municipal Health Commission. ZZJ and CL analyzed the data and wrote the manuscript. LWJ and ZQ performed the experiments. LHY, MHH, WD, ZYZ, WTY, and ZR made clinical contributions. ZT LHL, and HXT collected the samples. LZG analyzed the data. LZG, CL, and ZR designed the research, supervised the study, and revised the paper. All authors were involved in the final approval of the paper.