5. Conclusion
This study shows that AS-IV can reduce the acute inflammatory response induced by influenza virus in vitro . The potential mechanism may be that AS-IV inhibits the activation of NLRP3 inflammasome and reduces the secretion of inflammatory factors by inhibiting intracellular ROS levels after influenza virus infection. In addition, AS-IV alleviates lung tissue structural damage caused by poly (I: C) and reduces lung inflammation in vivo . These data promote the possibility of AS-IV in the future clinical treatment of viral pneumonia caused by influenza viruses. Our study also highlights antioxidants as one of the effective strategies to combat viral pneumonia.