5. Conclusion
This study shows that AS-IV can reduce the acute inflammatory response
induced by influenza virus in vitro . The potential mechanism may
be that AS-IV inhibits the activation of NLRP3 inflammasome and reduces
the secretion of inflammatory factors by inhibiting intracellular ROS
levels after influenza virus infection. In addition, AS-IV alleviates
lung tissue structural damage caused by poly (I: C) and reduces lung
inflammation in vivo . These data promote the possibility of AS-IV
in the future clinical treatment of viral pneumonia caused by influenza
viruses. Our study also highlights antioxidants as one of the effective
strategies to combat viral pneumonia.