3.1. AS-IV increases the cell viability of influenza-infected A549
cells but has no inhibitory effect on the influenza virus infection
Fig. 1A shows the chemical structure
of AS-IV. Fig. 1B-C shows the
toxicity of A549 cells treated with AS-IV for 72h. The results showed
that AS-IV had no obvious toxicity to cells when the concentration
reached 125µM, but when the concentration reached 250µM, AS-IV formed
many drug crystals, and the cell viability was significantly decreased
(P <0.01). Therefore, concentrations below 125µM were
used for subsequent experiments.