Effect of chitosan on quorum sensing
The results demonstrated that treatment of Pseudomonas aeruginosabacteria with chitosan concentrations of 10 and 100 μg/mL led to a
significant decrease in the production of pyocyanin and rhamnolipid, as
well as a reduction in swimming motility and protease activity compared
to the control group (P<0.05) (Fig 4). The greatest decrease
was observed at the concentration of 100 μg/mL chitosan. Furthermore,
treatment with chitosan resulted in a downregulation of the RhlR and
LasR genes in P. aeruginosa when compared to the control group
(P<0.05) (Figure 4).