Evidence synthesis

Comprehensive Meta-analysis software is used to compare the efficacy and safety of and control. The Odds ratio (OR) with 95% confidence interval (CI) was used for dichotomous variables. We conducted a pairwise meta-analysis for our analysis and reported summary effect estimates along with 95% confidence intervals (CIs) for each direct comparison. We included studies that provided data for at least two comparisons. The heterogeneity is defined as I2>50% and P <0.1. The random and fixed effect models were used for high and low heterogeneity studies, respectively.