4. Conclusion
In summary, the study demonstrates the protective effects of DACA against MPTP-induced motor dysfunction, neurological deficit, and neurodegeneration in a manner consistent. Additionally, DACA exhibits antioxidant properties and plays a crucial role in maintaining mitochondrial health and regulating mitophagy through Nrf2 activation (Fig. 1). These findings significantly contribute to our understanding of the intricate relationship between Nrf2 and Parkinson’s disease (PD). Consequently, DACA holds great promise as a potential anti-PD drug for further therapeutic interventions aimed at preventing PD occurrence and progression. However, it is imperative to conduct future investigations to explore other potential protective effects of DACA as well as its multi-target mechanism of action.