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Enhanced antioxidant activity of gold and silver nanoparticles of Scopoletin isolated from Sophora mollis
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  • Mohammed Mansour Quradha,
  • Rasool Khan,
  • Abdur Rauf,
  • Abdulkader Qahtan,
  • Sami Alnaqeep
Mohammed Mansour Quradha
Seiyun University

Corresponding Author:[email protected]

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Rasool Khan
University of Peshawar
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Abdur Rauf
University of Swabi
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Abdulkader Qahtan
Seiyun University
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Sami Alnaqeep
Alsaeed Foundation for Science and Culture
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This study aimed to increase the antioxidant potential of Scopoletin by utilizing green synthesis to create gold and silver nanoparticles. Pure Scopoletin was obtained from the aerial parts of S. mollis and identified using spectroscopic techniques The synthesized AuNPs and AgNPs were characterized using UV-visible spectroscopy, FT-IR spectroscopy, and scanning electron microscopy (SEM). The results indicated that the gold nanoparticles had diameters ranging from 58 to 81 nm, while the silver nanoparticles were spherical in shape with diameters ranging from 75 to 89 nm. The radical scavenging capacity of Scopoletin, AuNPs, and AgNPs was evaluated using the DPPH method. The highest radical scavenging capacity was exhibited by AgNPs, with a percentage inhibition of 76.114 ± 0.030% at a concentration of 400 µg/ml. In comparison, the highest radical scavenging capacity of AuNPs was 65.924 ± 0.018%, while the native compound showed weak activity at 16.641 ± 0.0955% at the same concentration. The results demonstrated an improved radical scavenging capacity of AgNPs and AuNPs, with ratios five and four times higher, respectively, compared to pure Scopoletin at the same concentration level. These findings suggest potential biomedical applications for the synthesized nanoparticles.
31 Jan 2024Submitted to Micro & Nano Letters
12 Feb 2024Assigned to Editor
12 Feb 2024Submission Checks Completed
13 Feb 2024Reviewer(s) Assigned
24 Feb 2024Review(s) Completed, Editorial Evaluation Pending