Conclusions
In summary, we have identified a relevant mouse model that mimics COVID-19 in humans. We have leveraged this model to explore the complex relationship between obesity and coronavirus disease severity. Our findings suggest that obesity contributes to increased susceptibility to severe coronavirus disease and may modulate tissue-specific responses. Moreover, the identification of potential biomarkers shared with severe COVID-19 cases in humans can be utilized to forecast disease outcomes, assess risk levels, and prognose high-risk patients to enable timely medical intervention. Future mechanistic studies are needed to elucidate the precise roles of these biomarkers in coronavirus disease outcomes.