Two or more neoplasia in family members before the age of 18
(including index case).
Parents or siblings with cancer before age 45
Two or more 1st or 2nd-degree relatives degree relatives in the same
family branch diagnosed with cancer before the age of 45.
Consanguinity of the patient’s parents
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1. Diagnosis of a type of tumor frequently associated with cancer
predisposition syndromes
2. Finding a previous mutation in the tumor analysis suggesting a
germline predisposition syndrome
3. Patient with 2 or more tumors (bilateral, multifocal, metachronous,
or secondary tumor)
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1. Phenotype compatible with a cancer predisposition syndrome
2.Patients with high toxicity to cancer treatment (toxicity not expected
with the type, degree, or duration of the treatment received)
|