Study Study design Country The name of cohort or data source study period Exposure of comparator group (disease status) Exposition period Sample size (exposed/ unexposed) or(case/control) Funding
Fejzo 2016 [33]
Cohort study
USA
The Hyperemesis Education and Research Foundation
2007-2014
Women who did not have a history of HG
NR
1070/771
Yes
ÖZDEMİRC 2014 [34] Cohort study Turkey NR 2006-2011 Chlorpromazine NR 100/85 NR
Colvin 2013 [35]
Cohort study
Australia
NR
2002–2005
Non-ondansetron
NR
251/96447
Yes
Berard 2019 [36]
Cohort study
Canada
The Quebec Pregnancy Cohort
1998-2015
Unexposed
The first trimester of pregnancy
31/224845
Yes
Asker 2005 [37] Cohort study Sweden The Swedish Medical Birth Registry 1995-2002 Unexposed First to third trimester 29804/665572 Yes
Dormuth 2021 [38]
Cohort study
Canada\USA\ UK Five Canadian provinces, the IBM Market Scan Research Databases from the US, and UK CPRD,
2002-2016
Unexposed
The first 84 days of gestation
185086/3927936
Yes
Lemon 2020 [39]
Cohort study
USA
Magee–Womens Hospital of the University of Pittsburgh Medical Center (UPMC)
2006-2014
No ondansetron
The first trimester
3733/29944
Yes
Einarson 2004 [40]
Cohort study
Canada
Teratogen Information Services (TIS)
NR
Other antiemetics/ Non-teratogen
NR
176/176/176
Yes
Huybrechts 2020 [41] Cohort study USA The Nationwide Medicaid Analytic eXtract (MAX) 2000-2014 Unexposed NR 23877/1856717 Yes
Suarez 2020 [42]
Cohort study
USA
The University of North Carolina (UNC) Health Care system
2014-2017
Comparators
NR
1742/935
Yes
Pasternak 2013 [43] Cohort study Denmark The Medical Birth Registry and the National Patient Register in Denmark 2004-2011 Unexposed The first trimester 1849/7396 Yes
Werler 2014 [44]
Case-control study
USA
NR
2007-2011
Controls
NR
646/2037
No
Zambelli-Weiner 2019 [45]
Case-control study
USA
US administrative health care database, the Truven Health Market Scan Commercial Database
2000-2014
Unexposed During Pregnancy
The first trimester
76330/787753
Yes
Sakran 2021 [46]
Case-control study
Israeli
The Israeli Teratology Information Service
2010-2014
Metoclopramide/NTE
NR
195/888
NR
Danielsson 2014 [47]
Case–control study
Sweden
The Swedish Medical Birth Register combined with the Swedish Register of Prescribed Drugs
1998-2012
Meclozine
10-12w
1349/1500085
NR
Parker 2018 [48]
Case–control study
USA
The National Birth Defects Prevention Study/the Slone Birth Defects Study
2005-2011/ 1997-2014
RxAE/No Treatment
NR
253/6498;375/5498
Yes
Couse 2020 [49]
Case report study
USA
NR
NR
NR
NR
NR
No
Lemon 2016 [50]
Case report study
USA
NR
NR
NR
NR
NR
Yes
Ferreira,2012 [51] Case series study USA NR 2002-2011 NR NR 14 NR