References
1. Yan H, He Z, Li Z, et al. Large Prefabricated Skin Flaps Based on the
Venous System in Rabbits: A Preliminary Study. Plastic and
Reconstructive Surgery 2013: 132: 372E-80E.
2. Shandalov Y, Egozi D, Koffler J, et al. An engineered muscle flap for
reconstruction of large soft tissue defects. Proceedings of the National
Academy of Sciences of the United States of America 2014: 111: 6010-15.
3. Angrigiani C, Rancati A, Artero G, Khouri RK, Jr., Walocko FM.
Stacked Thoracodorsal Artery Perforator Flaps for Unilateral Breast
Reconstruction. Plastic and Reconstructive Surgery 2016: 138: 969E-72E.
4. Chen G, Shen HG, Zang LL, et al. Protective effect of luteolin on
skin ischemia-reperfusion injury through an AKT-dependent mechanism.
International Journal of Molecular Medicine 2018: 42: 3073-82.
5. Deng C, Wu B, Wei Z, et al. A Systematic Study of Vascular
Distribution Characteristics and Axis Design of Various Flap Types.
Medical Science Monitor 2019: 25: 721-29.
6. Saito I, Hasegawa T, Ueha T, et al. Effect of local application of
transcutaneous carbon dioxide on survival of random-pattern skin flaps.
Journal of Plastic Reconstructive and Aesthetic Surgery 2018: 71:
1644-51.
7. Lin RJ, Chen HW, Callow D, et al. Multifaceted effects of
astragaloside IV on promotion of random pattern skin flap survival in
rats. American Journal of Translational Research 2017: 9: 4161-+.
8. Fukunaga Y, Izawa-Ishizawa Y, Horinouchi Y, et al. Topical
application of nitrosonifedipine, a novel radical scavenger, ameliorates
ischemic skin flap necrosis in a mouse model. Wound Repair and
Regeneration 2017: 25: 217-23.
9. Wu HQ, Ding J, Wang L, et al. Valproic acid enhances the viability of
random pattern skin flaps: involvement of enhancing angiogenesis and
inhibiting oxidative stress and apoptosis. Drug Design Development and
Therapy 2018: 12: 3951-60.
10. Rykx A, De Kimpe L, Mikhalap S, et al. Protein kinase D: a family
affair. Febs Letters 2003: 546: 81-86.
11. Wang QMJ. PKD at the crossroads of DAG and PKC signaling. Trends in
Pharmacological Sciences 2006: 27: 317-23.
12. Jaggi M, Du C, Zhang WG, Balaji KC. Protein kinase D1: a protein of
emerging translational interest. Frontiers in Bioscience-Landmark 2007:
12: 3757-67.
13. Hollenbach M, Stoll SJ, Jorgens K, Seufferlein T, Kroll J. Different
Regulation of Physiological and Tumor Angiogenesis in Zebrafish by
Protein Kinase D1 (PKD1). Plos One 2013: 8.
14. Zhao D, Wang W, Wang H, et al. PKD knockdown inhibits pressure
overload-induced cardiac hypertrophy by promoting autophagy via AKT/mTOR
pathway. International Journal of Biological Sciences 2017: 13: 276-85.
15. Dai SN, Hou AJ, Zhao SM, et al. Ginsenoside Rb1 Ameliorates
Autophagy of Hypoxia Cardiomyocytes from Neonatal Rats via AMP-Activated
Protein Kinase Pathway. Chinese Journal of Integrative Medicine 2019:
25: 521-28.
16. Avkiran M, Rowland AJ, Cuello F, Haworth RS. Protein kinase D in the
cardiovascular system - Emerging roles in health and disease.
Circulation Research 2008: 102: 157-63.
17. Venardos K, De Jong KA, Elkamie M, Connor T, McGee SL. The PKD
inhibitor CID755673 enhances cardiac function in diabetic db/db mice.
PLoS One 2015: 10: e0120934.
18. Sharlow ER, Giridhar KV, LaValle CR, et al. Potent and selective
disruption of protein kinase D functionality by a benzoxoloazepinolone.
J Biol Chem 2008: 283: 33516-26.
19. Yuan J, Liu Y, Tan T, et al. Protein kinase d regulates cell death
pathways in experimental pancreatitis. Front Physiol 2012: 3: 60.
20. Steinberg SF. Regulation of Protein Kinase D1 Activity. Molecular
Pharmacology 2012: 81: 284-91.
21. LaValle CR, George KM, Sharlow ER, et al. Protein kinase D as a
potential new target for cancer therapy. Biochimica Et Biophysica
Acta-Reviews on Cancer 2010: 1806: 183-92.
22. Brewer MB, Stump AL, Holton LH, et al. Effects of systemic tadalafil
on skin flap survival in rats. Eplasty 2012: 12: e45-e45.
23. He JB, Fang MJ, Ma XY, Li WJ, Lin DS. Angiogenic and
anti-inflammatory properties of azadirachtin A improve random skin flap
survival in rats. Experimental Biology and Medicine 2020: 245: 1672-82.
24. Wu H, Ding J, Wang L, et al. Valproic acid enhances the viability of
random pattern skin flaps: involvement of enhancing angiogenesis and
inhibiting oxidative stress and apoptosis. Drug Design Development and
Therapy 2018: 12: 3951-60.
25. Nowak-Sliwinska P, Alitalo K, Allen E, et al. Consensus guidelines
for the use and interpretation of angiogenesis assays. Angiogenesis
2018: 21: 425-532.
26. Brown LF, Yeo KT, Berse B, et al. VASCULAR-PERMEABILITY FACTOR
(VASCULAR ENDOTHELIAL GROWTH-FACTOR) IS STRONGLY EXPRESSED IN THE
NORMAL-MALE GENITAL-TRACT AND IS PRESENT IN SUBSTANTIAL QUANTITIES IN
SEMEN. Journal of Urology 1995: 154: 576-79.
27. Shi SR, Xie J, Zhong J, et al. Effects of low oxygen tension on gene
profile of soluble growth factors in co-cultured adipose-derived stromal
cells and chondrocytes. Cell Proliferation 2016: 49: 341-51.
28. di Blasio L, Droetto S, Norman J, Bussolino F, Primo LJT. Protein
kinase D1 regulates VEGF-A-induced alphavbeta3 integrin trafficking and
endothelial cell migration2010: 11: 1107-18.
29. Matthews SA, Liu P, Spitaler M, et al. Essential role for protein
kinase D family kinases in the regulation of class II histone
deacetylases in B lymphocytes. Molecular and Cellular Biology 2006: 26:
1569-77.
30. Ha CH, Wang W, Jhun BS, et al. Protein kinase D-dependent
phosphorylation and nuclear export of histone deacetylase 5 mediates
vascular endothelial growth factor-induced gene expression and
angiogenesis. Journal of Biological Chemistry 2008: 283: 14590-99.
31. Ha CH, Jin ZG. Protein kinase D1, a new molecular player in VEGF
signaling and angiogenesis. Molecules and Cells 2009: 28: 1-5.
32. Okamoto T, Usuda H, Tanaka T, Wada K, Shimaoka M. The Functional
Implications of Endothelial Gap Junctions and Cellular Mechanics in
Vascular Angiogenesis. Cancers 2019: 11.
33. Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9
triggers the angiogenic switch during carcinogenesis. Nature Cell
Biology 2000: 2: 737-44.
34. Cao J, Ehling M, Marz S, et al. Polarized actin and VE-cadherin
dynamics regulate junctional remodelling and cell migration during
sprouting angiogenesis. Nature Communications 2017: 8.
35. Cai L, Cao B, Lin D. Effects of Traditional Chinese Medicine Huangqi
Injection (Radix astragali) on Random Skin Flap Survival in Rats.
Journal of Reconstructive Microsurgery 2015: 31: 565-70.
36. Zembrzuska K, Ostrowski RP, Matyja E. Hyperbaric oxygen increases
glioma cell sensitivity to antitumor treatment with a novel isothiourea
derivative in vitro. Oncology Reports 2019: 41: 2703-16.
37. Sundram V, Chauhan SC, Jaggi M. Emerging Roles of Protein Kinase D1
in Cancer. Molecular Cancer Research 2011: 9: 985-96.
38. Asaithambi A, Kanthasamy A, Saminathan H, Anantharam V, Kanthasamy
AG. Protein kinase D1 (PKD1) activation mediates a compensatory
protective response during early stages of oxidative stress-induced
neuronal degeneration. Molecular Neurodegeneration 2011: 6.
39. Batinic-Haberle I, Tovmasyan A, Roberts ERH, et al. SOD
Therapeutics: Latest Insights into Their Structure-Activity
Relationships and Impact on the Cellular Redox-Based Signaling Pathways.
Antioxidants & Redox Signaling 2014: 20: 2372-415.
40. Storz P, Doppler H, Toker A. Protein kinase D mediates
mitochondrion-to-nucleus signaling and detoxification from mitochondrial
reactive oxygen species. Molecular and Cellular Biology 2005: 25:
8520-30.
41. Storz P. Mitochondrial ROS - radical detoxification, mediated by
protein kinase D. Trends in Cell Biology 2007: 17: 13-18.
42. Fuyuno Y, Uchi H, Yasumatsu M, et al. Perillaldehyde Inhibits AHR
Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes.
Oxidative Medicine and Cellular Longevity 2018: 2018.
43. Rah DK, Min HJ, Kim YW, Cheon YW. Effect of Platelet-Rich Plasma on
Ischemia-Reperfusion Injury in a Skin Flap Mouse Model. International
Journal of Medical Sciences 2017: 14: 829-39.
44. Elmore S. Apoptosis: A review of programmed cell death. Toxicologic
Pathology 2007: 35: 495-516.
45. Zhou KL, Zhou YF, Wu K, et al. Stimulation of autophagy promotes
functional recovery in diabetic rats with spinal cord injury. Scientific
Reports 2015: 5.
Figure legends