Animals and ethics statement
Wenzhou Medical University provided us with 250–300 g sixty male Sprague-Dawley (SD) rats. All experiments and animal care were done following the Guide for the Care and Use of Laboratory Animals of the China National Institutes of Health and approved by the Animal Care and Use Committee of Wenzhou Medical University (wydw2019-0954). SD rats were placed within a suitable environment with a twelve-hour light/dark cycle and sufficient water and food. Sixty rats were assigned in a random fashion to one group of the following: Control (n= 20), PKD1 (n= 20), or CID755673 (n= 20).