Rats’ mean blood pressure was measured.
The CODA Non Invasive Blood Pressure Recorder was used to measure mean
arterial blood pressure in conscious rats using the Tail-Cuff method
(Kent Scientific Corporation, USA). With the rat’s tail protruding, the
restrainer was inserted in the BP instrument. The rat’s restrainer was
placed in the BP instrument with its tail protruding. The tail was
gently pressed against a transducer mem-brane that was linked to the
digital BP display panel. After that, the device was turned on and
allowed to stabilise until a consistent pulse rate was seen. The BP
recording button was pressed and the mean arterial BP was recorded after
the ”pulse level ready” indicator showed. In this investigation, albino
rats (body weight 150-200 g) were employed. Rats were divided into four
groups, each with four individuals. After suspension in 0.1 carboxy
methyl cellulose (CMC) solution, each drug (10, 20, 40, and 60 mg/kg
body weight) was injected intraperitoneally. After 1 hour, the mean
arterial blood pressure was measured.