Rats’ mean blood pressure was measured.
The CODA Non Invasive Blood Pressure Recorder was used to measure mean arterial blood pressure in conscious rats using the Tail-Cuff method (Kent Scientific Corporation, USA). With the rat’s tail protruding, the restrainer was inserted in the BP instrument. The rat’s restrainer was placed in the BP instrument with its tail protruding. The tail was gently pressed against a transducer mem-brane that was linked to the digital BP display panel. After that, the device was turned on and allowed to stabilise until a consistent pulse rate was seen. The BP recording button was pressed and the mean arterial BP was recorded after the ”pulse level ready” indicator showed. In this investigation, albino rats (body weight 150-200 g) were employed. Rats were divided into four groups, each with four individuals. After suspension in 0.1 carboxy methyl cellulose (CMC) solution, each drug (10, 20, 40, and 60 mg/kg body weight) was injected intraperitoneally. After 1 hour, the mean arterial blood pressure was measured.