Statistical analysis of data:
GRAPHAD INSTAT 3 was used to do the statistical analysis (Graph Pad Software Inc, San Diego, CA). The results of animal trials were expressed as the arithmetic mean minus the standard error of the mean (SEM). One-way analysis of variance (ANOVA) was used to assess the effects of the various groups, and Dunnet’s multiple comparison tests were used to compare the effects of the treatment groups to the toxic control group. The significance level was set at p0.01. The MABP reduction % for each therapy group was also calculated and compared.