Study identification and selection
By searching PubMed, Embase, Cochrane Central Register of Controlled Trials, Clinical trials, CNKI, Wanfang Data, VIP, CBM database dated until August 2021. The database search identified 731 records. After removing duplicates, 692 titles were initially screened, and 9 theme-related abstracts were selected for further screening. 4 studies were excluded because data were not available. Finally, 5 studies were included in this systematic review(Fig. 1).(1, 2, 11, 18, 26) 4 used the values of the proportion of patients whose MRS score was 0-1 at day 90 in total,3 used the change in NIHSS score at 24 hours, 2 used the change in NIHSS score at day 7, 2 used the change in NIHSS score at day 90, 2 used the relative infarct lesion growth at 24 hours, 2 used the relative infarct lesion growth at day 7.