Statistical analysis
Data analysis of efficacy was
performed using statistical software provided by Revman5.3. Data
analysis of safety was performed using statistical software provided by
Stata16.0. For continuous variables, mean difference (MD) is adopted as
the effective index, and the point estimated value and 95% confidence
interval(CI) of each effect quantity are given. For the data of median,
maximum, and minimum values mentioned in the included study, combined
analysis is carried out after transformation according to the formula.
(25) The analysis was carried out for categorical variables using the
risk ratio (RR), LogRR, and its
95% CI. The heterogeneity included in the study was analyzed by the
X2 test (the test level was axiom 0.1) and evaluated
with the I2 index. Random effect karyotype is used for
Meta-analysis regardless of the I2 index.
The sensitivity analysis was to remove the individual studies in turn,
then reconduct the Meta-analysis and evaluate the difference between the
results after the exclusion and the original combined results. A p-value
of <0.05 was considered statistically significant. (24)