Statistical analysis
Data analysis of efficacy was performed using statistical software provided by Revman5.3. Data analysis of safety was performed using statistical software provided by Stata16.0. For continuous variables, mean difference (MD) is adopted as the effective index, and the point estimated value and 95% confidence interval(CI) of each effect quantity are given. For the data of median, maximum, and minimum values mentioned in the included study, combined analysis is carried out after transformation according to the formula. (25) The analysis was carried out for categorical variables using the risk ratio (RR), LogRR, and its 95% CI. The heterogeneity included in the study was analyzed by the X2 test (the test level was axiom 0.1) and evaluated with the I2 index. Random effect karyotype is used for Meta-analysis regardless of the I2 index.
The sensitivity analysis was to remove the individual studies in turn, then reconduct the Meta-analysis and evaluate the difference between the results after the exclusion and the original combined results. A p-value of <0.05 was considered statistically significant. (24)