RCTs: randomized clinical trials, FTY720:fingolimod, ST: standardized
treatment, ①the proportion of patients whose MRS score was 0,1 at day
90, ②the change of NIHSS scores over 24 hours,③the change of NIHSS
scores at day 7, ④ the change of NIHSS scores at day 90, ⑤relative
infarct lesion growth over 24 hours, ⑥relative infarct lesion growth at
day 7
Figure 2 shows the risk of bias assessment of the five randomized
trials; two trials described
adequate methods of random sequence generation, one trial described
allocation concealment. In four trials, the participants were blinded.
The rate of the dropout was low in all trials. None of these studies had
incomplete outcome data or selective outcome reporting. All five studies
had no other bias.