Fig. 3 Forest plot of the risk ratio of the proportion of patients whose
MRS score was 0-1 at day 90 between fingolimod plus standardized
treatment and standardized treatment alone.
Figure 4(A), including three articles, shows a forest plot of the mean
difference in the change in NIHSS score at 24 hours between fingolimod
plus standardized treatment and standardized treatment alone. This
finding suggested that the mean difference in NIHSS score change at 24
hours of fingolimod plus standardized treatment versus standardized
treatment alone was 2.78 (95%CI, 1.46 to 4.10). A random-effect model
was used. Sensitivity analyses were performed by removing each study in
turn and re-analyzed it. The application of sensitivity analysis showed
that the study by De-Cai Tian et al. 2017 significantly affected
heterogeneity. Figure 4(B), including two articles, shows a forest plot
of the mean difference in the change in NIHSS score at day 7 between
fingolimod plus standardized treatment and standardized treatment alone.
This finding suggested that the mean difference in NIHSS score change at
day 7 of fingolimod plus standardized treatment versus standardized
treatment alone was 2.59 (95%CI, -0.27 to 7.26). A random-effect model
was used. Figure 4(C), including two articles, shows a forest plot of
the mean difference in the change in NIHSS score at day 90 between
fingolimod plus standardized treatment and standardized treatment alone.
This finding suggested that the mean difference in NIHSS score change at
day 90 of fingolimod plus standardized treatment versus standardized
treatment alone was 3.98(95%CI, 1.15 to 6.80). A random-effect model
was used. Figure 4(D), including two articles, shows a forest plot of
the mean difference in the change in relative infarct lesion growth at
24 hours between fingolimod plus standardized treatment and standardized
treatment alone. This finding suggested that the mean difference in
relative infarct lesion growth change at 24 hours of fingolimod plus
standardized treatment versus standardized treatment alone was
-26.46(95%CI, -43.64 to -9.28). A random-effect model was used. Figure
4(E), including two articles, shows a forest plot of the mean difference
in the change in relative infarct lesion growth at day 7 between
fingolimod plus standardized treatment and standardized treatment alone.
This finding suggested that the mean difference in relative infarct
lesion growth change at day 7 of fingolimod plus standardized treatment
versus standardized treatment alone was -17.42(95%CI, -32.67 to -2.18).
A random-effect model was used.