Fig. 3 Forest plot of the risk ratio of the proportion of patients whose MRS score was 0-1 at day 90 between fingolimod plus standardized treatment and standardized treatment alone.
Figure 4(A), including three articles, shows a forest plot of the mean difference in the change in NIHSS score at 24 hours between fingolimod plus standardized treatment and standardized treatment alone. This finding suggested that the mean difference in NIHSS score change at 24 hours of fingolimod plus standardized treatment versus standardized treatment alone was 2.78 (95%CI, 1.46 to 4.10). A random-effect model was used. Sensitivity analyses were performed by removing each study in turn and re-analyzed it. The application of sensitivity analysis showed that the study by De-Cai Tian et al. 2017 significantly affected heterogeneity. Figure 4(B), including two articles, shows a forest plot of the mean difference in the change in NIHSS score at day 7 between fingolimod plus standardized treatment and standardized treatment alone. This finding suggested that the mean difference in NIHSS score change at day 7 of fingolimod plus standardized treatment versus standardized treatment alone was 2.59 (95%CI, -0.27 to 7.26). A random-effect model was used. Figure 4(C), including two articles, shows a forest plot of the mean difference in the change in NIHSS score at day 90 between fingolimod plus standardized treatment and standardized treatment alone. This finding suggested that the mean difference in NIHSS score change at day 90 of fingolimod plus standardized treatment versus standardized treatment alone was 3.98(95%CI, 1.15 to 6.80). A random-effect model was used. Figure 4(D), including two articles, shows a forest plot of the mean difference in the change in relative infarct lesion growth at 24 hours between fingolimod plus standardized treatment and standardized treatment alone. This finding suggested that the mean difference in relative infarct lesion growth change at 24 hours of fingolimod plus standardized treatment versus standardized treatment alone was -26.46(95%CI, -43.64 to -9.28). A random-effect model was used. Figure 4(E), including two articles, shows a forest plot of the mean difference in the change in relative infarct lesion growth at day 7 between fingolimod plus standardized treatment and standardized treatment alone. This finding suggested that the mean difference in relative infarct lesion growth change at day 7 of fingolimod plus standardized treatment versus standardized treatment alone was -17.42(95%CI, -32.67 to -2.18). A random-effect model was used.