Eosinophil degranulation
When sinonasal biopsies were stained with a high-affinity antibody to
detect both intracellular and released EPX, there was no change in
staining from baseline after mepolizumab (5.79±2.08 vs 6.07±1.20,
p=0.662), despite a 59% reduction in intact eosinophils. Interobserver
scoring of EPX staining showed excellent agreement (ICC 0.976).