Discussion
Hodgkin’s lymphoma is a type of blood cancer that responds to treatment.
This type of disease is considered uncommon. Chemotherapy is the first
line in controlling this disease. In the advanced stages of the disease
and in recurrent cases, a bone marrow transplant may be performed to
control the disease[18].
In general, marrow transplantation is divided into two main types
according to the source of stem cells, which are autologous bone marrow
transplantation where stem cells from patient and allogeneic bone marrow
transplantation, from a donor. There are many chemotherapeutic protocols
prior to marrow transplantation, in order to prepare the bone to receive
stem cells. These chemical protocols are in high doses and cause many
complications, including neutropenia and neutropenic
fever[19].
One of the treatments used in the treatment of neutropenic fever is the
liposomal Amphotericin-B
(Ambisome)[10].
A hypersensitivity reaction to liposomal Amphotericin has been reported
in many cases [20-24]. This is the
first case to report hypersensitivity to liposomal Amphotericin-B
(Ambisome) in patients with bone marrow transplantation in bone marrow
transplant center, Iraq. The allergy occurred from the first dose that
was given to the patient, and the situation was corrected by giving some
medications that reduced the sensitivity and improved the patient’s
condition. Although this is the first case of an allergic reaction to
liposomal Amphotericin-B recorded in our center, great care must be
taken in patients who take Liposomal Amphotericin-B, especially in the
first dose.
The approval of the bone marrow transplant center and the patient was
obtained in order to publish this data and study.