Key Results
ATO reduced atherosclerotic lesion formation and plasma lipid levels in
ApoE-/- mice. Additionally, it reduced the levels of
various pro-inflammatory factors, including IL-6 and TNFα, in the serum
and aortic plaques, but increased the IL-10 level. Mechanistically, ATO
promotes the CD36-mediated internalization of ox-LDL, which may explain
the reduction in blood lipid levels. Further, ATO reduced TLR4
expression in plaques and macrophages and inhibited LPS-induced p65
nuclear translocation and IκB-α degradation.