Background and Purpose
Inflammation and lipid accumulation are key events in atherosclerosis
progression. Arsenic trioxide (ATO) has been reported to prevent
vascular restenosis by promoting smooth muscle apoptosis and rapid
intimalisation. However, its specific role and mechanism
underlying its role in
atherosclerosis remain unknown. Herein, we evaluated whether ATO
suppresses atherosclerotic plaque development and instability.