Author contributions
XYZ, ZYL, LMY, and SHF designed experiments. XYZ drafted the manuscript. ZYL, LMY and SHF edited the manuscript. XW, SS, YNQ and XYZ performed the animal experiments; ZYL, SJW and YZ performed experiments in vitro. LMY provided crucial reagents. SHF and LMY take responsibility for accuracy of the analysis of the whole experiment.