Author contributions
XYZ, ZYL, LMY, and SHF designed experiments. XYZ
drafted the manuscript. ZYL, LMY and
SHF edited the manuscript. XW, SS, YNQ and XYZ performed the animal
experiments; ZYL, SJW and YZ performed experiments in vitro. LMY
provided crucial reagents. SHF and LMY take responsibility for accuracy
of the analysis of the whole experiment.