Arsenic trioxide
ameliorates atherosclerosis by
inhibiting CD36-induced endocytosis and TLR4/NF-κB-induced inflammation
in macrophage and ApoE-/- mice
Running title: ATO suppresses ox-LDL uptake, inflammation, and
atherosclerosis
Authors: Xiaoyi Zou2*, Zhaoying
Li1,2*, Xin Wan2,3, Song
Sun2,3, Shanjie Wang1,2, Yinan
Qu5, Yun Zhang6, Liming
Yang4†, Shaohong Fang1,2†
1Department of
Cardiology, The 2nd Affiliated Hospital of Harbin Medical University,
Harbin, Heilongjiang Province, China.
2The Key Laboratory of Myocardial Ischemia, Harbin
Medical University, Ministry of Education, Harbin, Heilongjiang
Province, China.
3Department of Neurobiology, School of Basic Medical
Sciences, Harbin Medical University, Harbin, Heilongjiang Province,
China.
4Department of Pathophysiology, Harbin Medical
University-Daqing, Daqing 163319, China.
5The Second XiangYa Hospital of Central South
University, Changsha, Hunan Province, China.
6Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX
77030 USA
*These authors contributed equally to this work: Xiaoyi Zou , Zhaoying
Li
†Correspondence:
Liming Yang: Department of Pathophysiology, Harbin Medical
University-Daqing, Daqing 163319, China Tel: E-mail:
limingyanghmu@163.com
Shaohong Fang: 246 Xuefu Road, Nangang District,
150086
Harbin, China, Tel: +86 451 8660 7221, E-mail: fangshaohong7802@163.com
Word coun t:3214
Acknowledgments:
These studies were funded by National Natural Science Foundation
Projects to Dr. Shaohong Fang (No.81870353,No.82170262); and Supported
by The 2nd Affiliated Hospital of Harbin Medical University,Harbin (No.
CX2016-21). Dr.Zou was granted by Key Laboratory of Myocardial
Ischemia,Ministry of Education (No.KF201809).