Conclusion and Implications
ATO has the potential atheroprotective effects, especially in macrophages. The mechanisms include inhibition of CD36-mediated foam cell formation, inflammatory responses, and pyroptosis via the suppression of TLR4/NF-κB and NLRP3 activation. Our findings provide evidence for the potential atheroprotective value of ATO.
Keywords : Arsenic trioxide, lipid metabolism, macrophage, pyroptosis, NLRP3 inflammasome