Arsenic trioxide ameliorates atherosclerosis by inhibiting CD36-induced endocytosis and TLR4/NF-κB-induced inflammation in macrophage and ApoE-/- mice
Running title: ATO suppresses ox-LDL uptake, inflammation, and atherosclerosis
Authors: Xiaoyi Zou2*, Zhaoying Li1,2*, Xin Wan2,3, Song Sun2,3, Shanjie Wang1,2, Yinan Qu5, Yun Zhang6, Liming Yang4†, Shaohong Fang1,2
1Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
2The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang Province, China.
3Department of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang Province, China.
4Department of Pathophysiology, Harbin Medical University-Daqing, Daqing 163319, China.
5The Second XiangYa Hospital of Central South University, Changsha, Hunan Province, China.
6Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77030 USA
*These authors contributed equally to this work: Xiaoyi Zou , Zhaoying Li
†Correspondence:
Liming Yang: Department of Pathophysiology, Harbin Medical University-Daqing, Daqing 163319, China Tel: E-mail: limingyanghmu@163.com
Shaohong Fang: 246 Xuefu Road, Nangang District, 150086 Harbin, China, Tel: +86 451 8660 7221, E-mail: fangshaohong7802@163.com
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Acknowledgments:
These studies were funded by National Natural Science Foundation Projects to Dr. Shaohong Fang (No.81870353,No.82170262); and Supported by The 2nd Affiliated Hospital of Harbin Medical University,Harbin (No. CX2016-21). Dr.Zou was granted by Key Laboratory of Myocardial Ischemia,Ministry of Education (No.KF201809).