CONCLUSION
In general, in hospitals in Brazil there are specific circumstances that interfere in the variation in the consumption of antifungal agents in the ICU, such as the profile of strains’ sensitivity to antifungal agents, the prescription practices and the epidemiology of the IFIs, which despite not being included in this study, influence the consumption of these agents. The vast majority of studies greatly reinforce the pattern of consumption of antimicrobials, emphasizing antibacterials, and this limits the number of studies that serve to counteract the results for systemic antifungal agents. Therefore, observing the variation in the consumption of these drugs helps to better assess the dispensing process and, consequently, their rational use. This pharmacoepidemiology practice, widely used in Europe in drug use studies, it is important not only for the knowledge and monitoring of adverse reactions and consumption, but also for the rationing of hospital expenses. According to the data, fluconazole showed a smaller growth trend in relation to the other studies compared, but it was still considered the most consumed drug in the analyzed period, different from itraconazole, which, with a reduced consumption density, was not very expressive in terms of use in the ICU, and voriconazole presented a growing scale of consumption, which shows its use in fungal infections in this sector.