Author contributions
Wen Zhang conceived the research, carried out the model building, performed the Western blot, coordinated the lab work and drafted the manuscript. Meng-meng Ge and Long-qing Zhang performed the statistical analysis and drafted the manuscript. Xiao-man Yuan and Si-yi Han took care of the NORT and drafted the manuscript. Anne Manyande, Xue-Bi Tian and Yu-Ke Tian participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.