Bullet point summary
What is already known
  1. The BDNF-TrkB signaling pathway plays a significant role in learning and memory impairment.
  2. ERK1/2, CaMK2, CREB, GluR1, and apoptosis are involved in learning and memory procession.
  3. 7,8-DHF is an effective agonist of the TrkB receptor which mimics the properties of BDNF.
What this study adds
  1. The BDNF-TrkB signaling pathway and its downstream cascades disorders involved in the LPS-induced learning and memory impairment in mice.
  2. 7,8-DHF could effectively alleviate cognitive dysfunction via acting on the TrkB in LPS mice.
  3. The mPFC, hippocampus and EC regions are associated with learning and memory procession.
Clinical significance
The BDNF-TrkB signaling pathway and its downstream cascade disorders are a new viewpoint for learning and memory impairments induced by neuroinflammation.
7,8-DHF might serve as a potential target for preventing or treating cognitive dysfunction induced by neuroinflammation in neurodegenerative diseases.