Bullet point summary
What is already known
- The BDNF-TrkB signaling pathway plays a significant role in learning
and memory impairment.
- ERK1/2, CaMK2, CREB, GluR1, and apoptosis are involved in learning and
memory procession.
- 7,8-DHF is an effective agonist of the TrkB receptor which mimics the
properties of BDNF.
What this study adds
- The BDNF-TrkB signaling pathway and its downstream cascades disorders
involved in the LPS-induced learning and memory impairment in mice.
- 7,8-DHF could effectively alleviate cognitive dysfunction via acting
on the TrkB in LPS mice.
- The mPFC, hippocampus and EC regions are associated with learning and
memory procession.
Clinical significance
The BDNF-TrkB signaling pathway and its downstream cascade disorders
are a new viewpoint for learning and memory impairments induced by
neuroinflammation.
7,8-DHF might serve as a potential target for preventing or treating
cognitive dysfunction induced by neuroinflammation in
neurodegenerative diseases.