Animals
Male c57BL/6J mice (8 weeks old) were obtained from the Experimental Animal Center of Tongji Medical College, Huazhong University of Science and Technology. A total of 106 mice were used in our research. Mice were raised five per cage under 12 hours light/dark cycle and given water and food ad libitum. All animal studies were approved by the Experimental Animal Committee of Tongji Medical college and in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.