Animals
Male c57BL/6J mice (8 weeks old) were obtained from the Experimental
Animal Center of Tongji Medical College, Huazhong University of Science
and Technology. A total of 106 mice were used in our research. Mice were
raised five per cage under 12 hours light/dark cycle and given water and
food ad libitum. All animal studies were approved by the Experimental
Animal Committee of Tongji Medical college and in accordance with the
National Institutes of Health Guide for the Care and Use of Laboratory
Animals.