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\begin{document}

\title{Study on compatibility of Banxia Baizhu Tianma Decoction on hypertension
treatment in rats}



\author[1]{Minhui li}%
\author[1]{huimin yang}%
\author[1]{yuxin gu}%
\author[1]{huijuan cheng}%
\author[1]{xue bai}%
\author[1]{lianhui men}%
\author[1]{feifei yang}%
\author[1]{cheng chen}%
\author[1]{wenqi li}%
\author[1]{zhihua huang}%
\author[1]{boting liao}%
\author[1]{honghua zhang}%
\author[1]{qingchang tian}%
\author[2]{nan xu}%
\author[3]{shuling wang}%
\affil[1]{Hangzhou Normal University Hangzhou School of Medicine}%
\affil[2]{Affiliation not available}%
\affil[3]{Hangzhou Normal University}%


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  \date{June 13, 2024}


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\begin{abstract}
Banxia Baizhu Tianma Decoction (BBTD), a classical compound of
traditional Chinese medicine (TCM), has been clinically used for
hypertension treatment. There are so many components in this formula
that it is necessary to explore whether each component plays a
positiverole in anti-hypertension treatment. After hypertension models
were established with high-fat diet for 6 weeks, rats in each group were
treated with full prescription, no principle prescription, no
ministerial prescription and no adjuvant prescription for 6 weeks
respectively. It was found that BBTD was effective in reducing body
weight gain, decreasing serum TG and T-CHO, as well as lowering
diastolic blood pressure (DBP) and systolic blood pressure (SBP). Total
28 metabolites in model rats were identified to be different from that
of control group, which focusing on 12 important metabolic pathways: (a)
Phenylalanine, Tyrosine and tryptophan biosynthesis, (b) Linoleic acid
metabolism, (c) Starch and sucrose metabolism, etc. Eight different
metabolites (Talose, Oleic acid, L-Proline, etc) were identified between
the full prescription group and the model group, which are mainly
involved in 4 metabolic pathways (Arginine and proline metabolism,
Biosynthesis of unsaturated fatty acids, Amino sugar and nucleotide
sugar metabolism and Aminoacyl-tRNA biosynthesis). Furthermore, it also
indicated that the principle drugs ie. Pinellia ternata and Gastrodia
elata was better than the other drug treatment. In a word, BBTD has a
therapeutic effect on hypertension in rats, and Pinellia ternata and
Gastrodia elata play an important role in the treatment. The study
provides theoretical basis for further optimization of BBTD formula.%
\end{abstract}%



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