Measures of treatment effect:
For dichotomous outcomes, we calculated a pooled estimate of the treatment effect for each outcome across trials as Risk Ratio (RR) with 95% confidence intervals (CIs). For continuous data, we calculated a pooled estimate of treatment effect by calculating the mean difference (MD) and standard deviation (SD) with corresponding 95% CIs. We used Review Manager software (Revman 5) to calculate the measures of treatment effect.