To investigate the prevalence of tocilizumab off-label prescribing in
outpatient department of a tertiary hospital and evaluate the
rationality of these off-label prescriptions by looking through
scientific evidences. Setting Peking Union Medical College Hospital in
Beijing in China. Method Retrieving one year tocilizumab related
prescriptions from hospital electronic information system. The standard
of evaluating the on-label or off-label prescription according to
whether the indication approved by China. Logistic regression was
applied to explore predictive variables. All of the literature source
acquired from Up-To-Date, Micromedex database, PubMed, Embase, and
clinical guidelines. Main outcome measure The percentage of off-label
use, influence factors identified by logistic regression, the
rationality of off-label use. Conclusion according to our analysis, the
majority of off-label indications of tocilizumab in our hospital have
evidence support. But some indications were supported by low grade
scientific evidence, more studies are required to confirm the clinical
values. For the indication that has no evidence support, we suggest the
administration should strength supervision.