Immunosuppressive Therapy Adherence as Assessed by Adherence
Rate
Adherence rate assessed by electronic equipmentA total of 6 RCTs (20 , 21 , 24 -27 ) reported
immunosuppressant adherence rate, and we were able to extract 3 sets
of analyzable data from 5 RCTs with 344 participants in the
meta-analysis. The
random-effects model was used in
this analysis owing to the moderate heterogeneity (I²=53%, p=0.09).
Results from the meta-analysis
showed that participants in the eHealth intervention groups showed
significantly increased adherence rate as compared with those in the
routine intervention groups with a pooled RR = 1.46 (95%CI: 1.11 to
1.90, p=0.006)(Figure 4). We did not include Henriksson et al.
(27 ) because it only reported compliance rates (97.8%) in the
intervention group, without an electronic medication dispener to
record medication in control group. Low et al. (26 ) did not
give specific adherence rates, but instead presented the results in
the form of a picture, they found no difference between the eHealth
intervention and control groups. The study of Schmid et al.
(25 ) was not included in
this analysis as a comprehensive adherence rate (combination of
tacrolimus trough levels, collateral reports, and self-reported
adherence rates) was used for analysis in that study.