Abstract
Objective: To analyze the correlation between iron status and
thyroid hormone in pregnant women during their second trimester of
pregnancy.
Design: A hospital-based case-control study.
Population: A total of 550 pregnant women were recruited from
Pingguo Maternity and Child Health Hospital.
Method: Data was grouped by SF concentration, and was performed
by correlation and regression analysis.
Main outcome measure: Iron nutritional status and thyroid
hormones.
Results: A significant difference was found in thyroid hormone
level, including FT3, FT4, and TSH (all P < 0.01)
between two groups (Mann-Whitney U test), and the levels of FT3 and FT4
were significantly lower in the iron deficiency group. Spearman’s
correlation analysis showed that both of SF and Hb were correlated with
FT3, FT4, and TSH (all P < 0.01). Canonical correlation
was used to analyze the interrelationships between iron status and
thyroid hormones, showing SF was positively associated with the FT3
level. The elastic network regression
indicated that the coefficient of Hb was greater than that of SF.
Conclusion: Our study indicated that
iron nutritional status is associated
with thyroid hormone levels during the second trimester of pregnancy,
suggesting that ID may be an important risk factor in thyroid hormone
levels. Involving two common endocrine diseases in pregnancy, the
relationship between ID and thyroid hormone deserves further
investigation.
Tweetable abstract: Iron nutritional status is associated with
thyroid hormone levels during the second trimester of pregnancy.