Results
The median age turned out to be 42 (19-82) in the Covid‐19 pneumonia, 33
(19-81) in Covid-19 patients without pneumonia and 34 (19-87) in the
healthy group (Table 1). The median age was significantly higher in the
pneumonia group than those without pneumonia (p <0.001) and
healthy controls (p <0.001). Although the gender distribution
in the Covid‐19 pneumonia group was 43% (75) women and 57% (99) men,
it was 45.8% (66) women and 54.2% (78) men in those without pneumonia.
WBC, neutrophil, platelet and lymphocyte levels remained significantly
low (Table 2) in patients with and without pneumonia compared to healthy
subjects (both p <0.001). When we compared WBC, neutrophil,
lymphocyte and platelet levels of Covid-19 patients with pneumonia to
those without we found no difference (p=0.482, 0.923, 0.164 and 0.447
respectively). Covid-19 patients with pneumonia had the lowest monocyte
levels compared to those without pneumonia and healthy controls (Both p
<0.001) but we found no difference between Covid-19 patients
without pneumonia and healthy controls (p=0.261). Eosinophil levels were
lower in patients with Covid-19 pneumonia compared to those without and
healthy controls as well as in Covid-19 patients without pneumnoia
compared to healthy controls (p <0.001 for three comparisons).
There was no difference between MPV, RDW, PDW and NLR levels of all
groups. MLR was higher in Covid-19 patients without pneumonia compared
to those with pneumonia and healthy controls (both p <0.001)
yet no difference between patients with pneumonia versus healthy
controls (p=0.045). PLR was higher in Covid-19 patients without
pneumonia compared to control group (p <0.001) but no
difference when compared to those with pneumonia (p=0.025) and patients
with pneumoia compared to healthy controls (p=0.013). We found no
difference between PLR of Covid-19 patients with and without pneumonia
(p=0.025). We analyzed the optimal cut-off values calculated by the ROC
analysis, and the ROC curves are presented in Figure 1, Figure 2. When
we compared Covid-19 patients with pneumonia to healthy controls the
areas under the curve (AUC) of WBC, Neutrophil, Lymphocyte, Monocyte,
Eosinophil and Platelet were found as 0.828 (p < 0.0001),
0.769 (p <0.001), 0.727(p <0.001), 0.657 (p
< 0.0001), 0.815 (p <0.0001) and 0.688 (p
<0.001) respectively (Table 3). For MLR and PLR 0.574 (p
=0.21), 0.591 (p =0.05) respectively (Table 3). When we compared
Covid-19 patients without pneumonia to healthy controls AUC of WBC,
Neutrophil, Lymphocyte, Eosinophil, Platelets, Monocyte, MLR and PLR
were found as 0.826 (p < 0.0001), 0.775 (p <0.001),
0.756 (p <0.001), 0.724 (p < 0.0001), 0.684 (p
< 0.0001), 0.535 (p = 0.304), 0.714 (p <0.001) and
0.657 (p <0.001) respectively (Table 4). Significant levels
for comparison between Covid-19 patients with and without pneumonia were
observed between monocyte levels (AUC 0.66 P <0.001) and
Eosinophil levels (AUC 0.612 P <0.001).