MSCs-EXO suppress inflammation via the MAPK pathway
As shown in Figure 6, the mRNA levels of JUN , FOS ,ERK , JNK , IKB , and IKK were significantly
higher in the AR group than in the control group, while the mRNA levels
of JUN , FOS , ERK , and JNK were significantly
lower in the MSCs-Exo group than in the AR group but higher than in the
control group. Furthermore, there were no differences in the mRNA levels
of IKK and IKB between the AR group and the MSCs-Exo
group. These results imply that AR might stimulate inflammation by
activating the MAPK and NF-κB pathways, while MSCs-Exo alleviates
inflammation by inhibiting the MAPK pathway.