ABSTRACT
PURPOSE:
The aim of this study was to evaluate the efficacy of 1.5T MRI using
lesion length (LL) and tumor-capsule contact length (TCL) in detecting
extraprostatic extension (EPE) in prostate cancer (PCa).
MATERIALS and METHODS:
A total of 110 patients who underwent radical prostatectomy due to PCa
were enrolled. Preoperative MR images of the patients were evaluated
retrospectively by two independent observers who did not know the
histopathological results. The observers evaluated LL and TCL. The
radiological findings, including lesion location, were verified using
histopathological mapping.
RESULTS:
Multiparametric MR examination of the prostate demonstrated low
sensitivity but high specificity, with significant differencesfor
detecting EPE (Observer 1, p < 0.0001; Observer 2, p = 0.003).
The increased PI-RADS score correlated positively with the increased EPE
rate. The LL and TCL demonstrated a statistically significant difference
between patients with and without EPE. The TCL was a significant
parameter for EPE, with high sensitivity and low specificity for both
observers. Cut-off values were obtained for both the LL and TCL.
CONCLUSION:
The results revealed that 1.5T MRI demonstrated low sensitivity and high
specificity in detecting EPE. The LL and TCL may be beneficial
indirectly in detecting EPE.
Keywords: Prostate Cancer; Capsular Invasion; Extraprostatic Extension;
Multiparametric Prostate MR; Tumor-Capsule Contact Length