Statistical analysis
Statistical analysis focused on the ADR events according to the risk
drug prescription and HLA genotype status. Categorical variables were
compared between the two groups, with and without HLA risk alleles. A 2
× 2 table was made for each prescribed drug to compare the frequencies
of patients with HLA PGx alleles and ADR occurrence. TheP -values, odds ratios (OR), and 95% confidence intervals (CI)
were calculated using a two-tailed Fisher’s exact test. A P -value
less than 0.05 was considered statistically significant. Haldane’s
correction was used by adding 1 to all cells if a SCAR or type B ADR was
not reported in patients without the HLA PGx
alleles.13 Haldane’s correction was not used if a SCAR
or type B ADR was not reported in patients with the HLA PGx alleles. All
analyses were conducted using the R statistical software version
3.0.2.14