Methods
A retrospective study in a cohort of post-operated patients with A.V.R.
between January 1995 and January 2020. We included patients older than
18 years of age who met diagnostic criteria for severe valve
dysfunction14, and the Heart Team decided to perform
AVR using a biological or mechanical prosthesis15. All
patients with signed informed consent format. Were excluded Patients
with other cardiac intervention in addition to AVR, with significant
coronary artery disease, immunodeficiency, and oncological or rheumatic
disease
We included for the evaluation a control group with 80 healthy subjects
matched by age and gender.
We extracted from the clinical record and performed a two-dimensional
transthoracic echocardiogram (TTE) before surgery, following the
evaluation and recommendations for measuring the heart
chambers16 to rule out structural abnormalities and
valvular dysfunction. Through brachial venipuncture, blood samples were
obtained for the quantification of inflammatory mediators. Pre and
postoperative data were collected.
Enrollment did not imply additional diagnostic procedures to sampling
and no alternative or additional treatments were performed. Data
management was carried out in order to make identification of an
individual patient and the need for consent was required. The protocol
was approved by the local Ethics Committee Number 19-1139 and the
registry in Clinical Trials NCT04557345