Study subjects
This cohort is part of an ongoing clinical trial CRITICAL (Cockroach Immunotherapy in Children and Adolescents; https://clinicaltrials.gov/ct2/show/NCT03541187). Subjects were enrolled if they were IgE sensitized to CR antigen (measured by skin prick testing and serum IgE) and were ages 8 through 17 with well-controlled asthma (mild-moderate persistent) at study entry (Table 1) . Clinical characteristics and evaluation are detailed in the online supporting information.