RESULTS
This study consisted of 55 cases (18 IHCP and 37 control). Comparison of demographic features was summarized in Table 1. There was no statistically significant difference between IHCP and control group in terms of maternal demographic characteristics and obstetric history except parity (p=0,02).
Umbilical artery, middle cerebral artery and pulmonary artery Doppler flow indices were summarized in Table 2. Regarding the Doppler findings, mean pulmonary artery AT, ET, PATET and peak systolic velocity values were statistically significant different between the groups (p=0,001; p=0,024 and p=0,003, respectively). The mean PATET value in the IHCP group was 0,217 ± 0,029 while in the control group it was 0,180 ± 0,020 (p=0,003). Mean maternal serum bile acid value was 27,8 ± 16,3 mmol/L.
In Table 3, birth characteristics, umbilical venous blood gas analysis, NICU admission and respiratory distress values were compared. The comparisons regarding to type of delivery, administration of antenatal corticosteroid, APGAR scores at the first and fifth minutes and respiratory distress were not statistically significant, but gestational age at birth and birthweight were different (p=0,001 and p:0,034). As statistically different, lower pH values and higher pCO2values were detected in the IHC group. Acidemia was not detected in any of them.
In the IHCP group, 8 (44,4%) newborns admitted to NICU and 5 (27,7%) of them had respiratory distress. Besides, 3(8%) newborns in the control group admitted to NICU due to respiratory distress. When NICU admission and respiratory distress values were compared, NICU admission was significantly different but respiratory distress was not found (p:0,012 and p:0,096, respectively). APGAR score at fifth minutes, gestational age at birth and respiratory distress were significantly correlated with NICU admission. Moderate negative correlations between gestational age at birth (r=-.471 p=0,001) , APGAR score at fifth minutes (r=-.294 p=0,031) and NICU admission were found. A moderate correlation between respiratory distress (r=,372 p:0,006) and NICU admission was found. While PATET values were correlated with gestational age at birth, respiratory distress and NICU admission were not correlated with PATET.