RESULTS
Specific pharmacokinetic parameters were calculated to evaluate the
effect of TPE on CFP and SUL. The amount of drug eliminated during TPE
(QPE) were 395.75±147.38 and 35.25±11.32 mg,
respectively. Percentage eliminated by TPE (fe %) were
11.38±3.18% and 2.74±1.13%, respectively. Calculated percentages of
total drug clearance by TPE (%CLPE) were 27.71±10.8%
and 6.16±2.16%, respectively. There were no significant differences in
pharmacokinetic parameters (AUC0-8,
Vd, T1/2a) between
session I and session II for both CFP and SUL.