Patients
This was a prospective, single-center study conducted in the
Hemato-oncological intensive care unit of the first affiliated hospital
of Harbin Medical University between Mar 2020 and June 2021. Critically
ill TTP patients with suspected or confirmed infections who received
CFP/SUL as an empirical or targeted
therapy became candidates for this research. Patient characteristics and
clinical data, including demographic data (sex, age, high weight), type
of infection, and organ function characteristics were collected.
TTP was diagnosed based on current
expert statements regarding the ICU management of patients with TTP
[11]. The study was approved by the ethics committee of the
participant hospital, and the study was conducted in adherence to the
Declaration of Helsinki. Written informed consent was obtained from the
patient designated decision-maker.