Conclusion
In general, we firstly describe the
pharmacokinetics of CFP and SUL in
critically ill TTP patients undergoing TPE. Results confirmed that Vd
and Pb are the two dominant factors determining drug elimination by TPE.
CFP is more likely to be removed than SUL during TPE due to its a small
Vd and high Pb. However, the amount of CFP and SUL removed by TPE may
not be clinically significant, and dosages should not be adjusted in
critically ill TTP patients undergoing TPE.