Patients
This was a prospective, single-center study conducted in the Hemato-oncological intensive care unit of the first affiliated hospital of Harbin Medical University between Mar 2020 and June 2021. Critically ill TTP patients with suspected or confirmed infections who received CFP/SUL as an empirical or targeted therapy became candidates for this research. Patient characteristics and clinical data, including demographic data (sex, age, high weight), type of infection, and organ function characteristics were collected.
TTP was diagnosed based on current expert statements regarding the ICU management of patients with TTP [11]. The study was approved by the ethics committee of the participant hospital, and the study was conducted in adherence to the Declaration of Helsinki. Written informed consent was obtained from the patient designated decision-maker.