METHODS
Critically ill TTP patients receiving a dose of 3 g CFP/SUL (2.0 g/1.0
g) intravenously every 8 h were included in the study. Serial blood
samples were collected at 0, 1, 2, 3, 4, 6, and 8 h at the third
infusion with TPE (Session I) and the sixth infusion without TPE
(Session II). Effluent samples were also collected at the effluent port
of plasma eliminated during TPE. Concentrations of CFP and SUL in plasma
and effluent were measured using LC/MS/MS.