CYTOKINE RELEASE SYNDROME AFTER TISAGENLECLEUCEL INFUSION IN PEDIATRIC PATIENTS WITH REFRACTORY/RELAPSED B-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA: IS THERE A ROLE FOR DICLOFENAC?
Sara Napolitano, MD1, Giorgio Ottaviano, MD2, Laura Bettini, MD3, Vincenzo Russotto, MD4, Sonia Bonanomi, MD1, Attilio Rovelli, MD1, Andrea Biondi, MD1,5, Roberto Rona, MD4, Adriana Balduzzi, MD1,5
1Hematology-Oncology and Bone Marrow Transplantation Unit, Pediatric Dept., Monza and Brianza Foundation for Children and their Mums, San Gerardo Hospital, Lombardia, Monza, Italy
2Molecular and Cellular Immunology Unit, University College of London, Great Ormond Street Institute of Child Health, London, United Kingdom
3Monza and Brianza Foundation for Children and their Mums, Tettamanti Laboratory , Monza, Lombardia, Italy
4 Department of Emergency and Intensive Care, University Hospital San Gerardo, Monza, Italy
5 University of Milan–Bicocca, Monza, Italy
* Correspondence to:
Sara Napolitano, Pediatrician, Clinica Pediatrica, Università’ degli Studi di Milano Bicocca, Monza, Italy; Contact Information: Fondazione MBBM / Ospedale San Gerardo, Via Pergolesi 33, 20900 Monza (MB), Italy, tel +39 039-233.2442, fax .3523, e-mail:snapolitano@fondazionembbm.it
Main text word count: 2524
Abstract word count: 244
BRIEF RUNNING TITLE: diclofenac management for Cytokine Release Syndrome.
Keywords: Gene Therapy, cytokine therapy, acute lymphoblastic leukemia (ALL), childhood
Number of Figures: 1
Number of Tables: 3